Recent Advances in Physiotherapy Intervention on Patellofemoral Pain Syndrome - A Systemic Review
Abstract
Background: Patellofemoral Pain Syndrome (PFPS) is a prevalent knee condition characterized by anterior or retro patellar pain, often triggered by activities like climbing stairs, squatting, or prolonged sitting. It arises from multifactorial causes, including malalignment, muscular imbalances, and biomechanical abnormalities. Recent physiotherapy advancements aim to enhance pain management, muscle function, and knee stability, emphasizing patient-centered approaches.
Methodology: Eligible studies included randomized controlled trials (RCTs), cohort studies, and case series focusing on patients with PFPS. Data extraction encompassed patient demographics, intervention protocols, and outcome measures, including the Visual Analog Scale (VAS) and Anterior Knee Pain Scale (AKPS).
Results: The review synthesized findings from 10 RCTs with 1,472 participants. Neuromuscular training, kinesiology taping, high-intensity laser therapy, and patient education were identified as effective short-term interventions. Combined therapies demonstrated superior outcomes in pain reduction, functional improvement, and muscle strength compared to isolated approaches. However, variations in follow-up durations and small sample sizes limited insights into long-term efficacy.
Conclusion: This review highlights the need for a multifaceted, individualized treatment approach for PFPS. Neuromuscular stimulation, targeted exercise, and patient education emerged as effective strategies for pain management and functional recovery. Future research should focus on long-term outcomes and the integration of patient-specific biomechanics into treatment protocols.
References
Hu H, Zheng Y, Liu X, Gong D, Chen C, Wang Y, et al. Effects of neuromuscular training on pain intensity and self-reported functionality for patellofemoral pain syndrome in runners: study protocol for a randomized controlled clinical trial. Trials. 2019 Jul 9;20(1):409
Hott A, Liavaag S, Juel NG, Brox JI. Study protocol: a randomized controlled trial comparing the long-term effects of isolated hip strengthening, quadriceps-based training, and free physical activity for patellofemoral pain syndrome (anterior knee pain). BMC Musculoskelet Disord. 2015 Feb 25;16:40
Rabelo ND, Lima B, Reis AC, Bley AS, Yi LC, Fukuda TY, et al. Neuromuscular training and muscle strengthening in patients with patellofemoral pain syndrome: a protocol of randomized controlled trial. BMC Musculoskelet Disord. 2014 May 16;15:157.
Collado H, Fredericson M. Patellofemoral pain syndrome. Clin Sports Med. 2010 Jul;29(3):379-98.
Ismail MM, Gamaleldein MH, Hassa KA. Closed kinetic chain exercises with or without additional hip strengthening exercises in the management of patellofemoral pain syndrome: a randomized controlled trial. Eur J Phys Rehabil Med. 2013 Oct;49(5):687-98.
Rabelo ND, Lima B, Reis AC, Bley AS, Yi LC, Fukuda TY, et al. Neuromuscular training and muscle strengthening in patients with patellofemoral pain syndrome: a protocol of randomized controlled trial. BMC Musculoskelet Disord. 2014 May 16;15:157.
Nie Q, Yu Y, Yuan Z, Chen J. Effects of adding neuromuscular electrical stimulation to functional training on muscle recruitment, pain reduction, and knee joint function in patellofemoral pain syndrome patients. Medicine (Baltimore). 2024 Jan 19;103(3):e36095.
Yoon S, Son H. Effects of McConnell and Kinesio Tapings on Pain and Gait Parameters during Stair Ambulation in Patients with Patellofemoral Pain Syndrome. Medicina (Kaunas). 2022 Sep 4;58(9):1219. doi: 10.3390/medicina58091219.
Arrebola LS, Teixeira de Carvalho R, Lam Wun PY, Rizzi de Oliveira P, Firmo Dos Santos J, Coutinho de Oliveira VG, Pinfildi CE. Investigation of different application techniques for Kinesio Taping® with an accompanying exercise protocol for improvement of pain and functionality in patients with patellofemoral pain syndrome: A pilot study. J Bodyw Mov Ther. 2020 Jan;24(1):47-55. doi: 10.1016/j.jbmt.2019.05.022. Epub 2019 May 22.
Lee JH, Rhim HC, Jang KM. Effect of Adding Kinesio Taping to Exercise Therapy in the Treatment of Patellofemoral Pain Syndrome. Medicina (Kaunas). 2023 Apr 12;59(4):754. doi: 10.3390/medicina59040754. PMID: 3710971; .
Mv VK, Subramanian NB, S S, Kotamraju S, Krishnan M. Physiotherapeutic interventions on quadriceps muscle architecture in patello-femoral pain syndrome. Bioinformation. 2023 Apr 30;19(4):454-459. doi: 10.6026/97320630019454.
Kochar SS, Fating T, Patil S. Efficacy of Isometric Exercises and Somatosensory Training for Pain, Proprioception, and Balance in Runners with Patellofemoral Pain Syndrome. Cureus. 2024 Mar 14;16(3):e56163. doi: 10.7759/cureus.56163.
Hu H, Zheng Y, Liu X, Gong D, Chen C, Wang Y, Peng M, Wu B, Wang J, Song G, Zhang J, Guo J, Dong Y, Wang X. Effects of neuromuscular training on pain intensity and self-reported functionality for patellofemoral pain syndrome in runners: study protocol for a randomized controlled clinical trial. Trials. 2019 Jul 9;20(1):409. doi: 10.1186/s13063-019-3503-4.
Ozlu O, Atilgan E. The effect of high-intensity laser therapy on pain and lower extremity function in patellofemoral pain syndrome: a single-blind randomized controlled trial. Lasers Med Sci. 2024 Apr 17;39(1):103. doi: 10.1007/s10103-024-04017-y.
Hong QM, Wang HN, Liu XH, Zhou WQ, Zhang X, Luo XB. Home-based exercise program and Health education in patients with patellofemoral pain: a randomized controlled trial. BMC Musculoskelet Disord. 2023 Nov 18;24(1):896. doi: 10.1186/s12891-023-07027-z.
Kamel AM, Ghuiba K, Abd Allah DS, Fayaz NA, Abdelkader NA. Effect of adding short foot exercise to hip and knee focused exercises in treatment of patients with patellofemoral pain syndrome: a randomized controlled trial. J Orthop Surg Res. 2024 Apr 1;19(1):207. doi: 10.1186/s13018-024-04688-x.
Copyright (c) 2025 Aishwarya K, Smruti Swagatika Dash, Rajendra Kachhwaha

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The International Journal of Innovative Science & Technology affairs require a formal written transfer of copyright from the author(s) for each article published. We therefore ask you to complete and return this form, retaining a copy for your records. Your cooperation is essential and appreciated. Any delay will result in a delay in publication.
I/we have read and agree with the terms and conditions stated Page 2 of this agreement and I/we hereby confirm the transfer of all copyrights in and relating to the above-named manuscript, in all forms and media, now or hereafter known, to the International Journal of Drug Regulatory affairs, effective from the date stated below. I/we acknowledge that the IJDRA is relying on this agreement in publishing the above-named manuscript. However, this agreement will be null and void if the manuscript is not published in the IJIST.
Download link for COPYRIGHT FORM